MYELOID NEOPLASIA Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation
نویسندگان
چکیده
1Division of Pediatric Hematology/Oncology, Children’s Hospital at Montefiore, Bronx, NY; 2Department of Cell Biology, Albert Einstein College of Medicine and Albert Einstein Cancer Center, Bronx, NY; 3Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY; 4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; 5Department of Medicine, Harvard Medical School, Boston, MA; 6Department of Developmental and Molecular Biology, Albert Einstein College of Medicine and Albert Einstein Cancer Center, Bronx, NY
منابع مشابه
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.
Eltrombopag (EP) is a small-molecule, nonpeptide thrombopoietin receptor (TPO-R) agonist that has been approved recently for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura. Prior studies have shown that EP stimulates megakaryopoiesis in BM cells from patients with acute myeloid leukemia and myelodysplastic syndrome, and the results also suggested that...
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تاریخ انتشار 2012